Bone resorption inhibitors
AssigneeJapan as represented by Secretary of National Institute of Infectious Diseases
InventorsKazuo Suzuki, Satoshi Yamagoe, Tooru Yamakawa
Life of this patent
Estimating the term…
Abstract
A leukocyte activating protein factor or a substance originating therein having an effect of inhibiting bone resorption; and novel medicinal utilization thereof. Use of these novel substances with the bone resorption inhibitory effect makes it possible to provide therapeutic methods efficacious against hypercalcemia, osteoporosis, etc.
Claims20
A bone resorption inhibitor composition comprising leukocyte activating protein factor or leukocyte activating protein factor-derived substances having an amino acid sequcnce of SEQ ID NO. 2, that is produced utilizing gene technology in an amount effective for bone resorption inhibitory activity.
A bone resorption inhibitor composition comprising leukocyte activating protein factor or leukocyte activating protein factor-derived substances, wherein the leukocyte activating protein factor has sequences of amino acid number 19 to 151 of SEQ ID NO. 2.
A screening method for bone resorption inhibitor derived substances containing leukocyte activating protein factor or leukocyte activating protein factor-derived substances having an amino acid sequence of SEQ ID NO. 1, which are purified from the source of these substances, or which are prepared by or synthesized based on the information of these substances, comprising providing said derived substances and deterring bone resorption inhibitory activity of the derived substances using percent inhibition of pit formation.
A method of producing bone resorption inhibitor comprising using leukocyte activating protein factor or leukocyte activating protein factor-derived substances having an amino acid sequence of SEQ ID NO. 1 in the production of bone resorption inhibitors.
A method for bone resorption inhibiting in an animal comprising administering to said animal an effective amount of bone resorption inhibitor derived substances containing leukocyte activating protein factor or leukocyte activating protein factor-derived substances having an amino acid sequence of SEQ ID NO. 1.
A method of producing bone resorption inhibitor comprising:
- providing leukocyte activating protein factor or leukocyte activating protein factor-derived substances;
- and
- using the leukocyte activating protein factor or the leukocyte activating protein factor-derived substances in the production of bone resorption inhibitors,
- wherein the leukocyte activating protein factor or leukocyte activating protein factor-derived substance has an amino acid sequence of SEQ ID NO. 1.
A method for bone resorption inhibiting in an animal comprising:
- providing a bone resorption inhibitor derived substance containing at least one leukocyte activating protein factor or leukocyte activating protein factor-derived substance;
- and
- administering to said animal an effective amount of a bone resorption inhibitor derived substance containing leukocyte activating protein factor or leukocyte activating protein factor-derived substances,
- wherein the bone resorption inhibitor derived substances containing leukocyte activating protein factor or leukocyte activating protein factor-derived substances has an amino acid sequcnce of SEQ ID NO. 1.
Dependencies are inferred from the claim text.