US 6,723,343 B2Granted

Pharmaceutical tramadol salts

AssigneeGruenenthal GmbH

InventorHeinrich Kugelmann

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Abstract

Disclosed are a compound of tramadol and a sugar substitute, pharmaceutical compositions and sustained-release formulations comprising the compound, and methods of treatment using the compound. The tramadol compound according to the present invention has reduced bitter taste of tramadol and is more acceptable to the patient.

Claims29

Dependent claims

A pharmaceutically acceptable salt of tramadol and a sugar substitute, wherein the solubility of the salt in water or aqueous body fluids is <100 mg/ml.

Dependencies are inferred from the claim text.

Facts

Application: 10/084,682Filed 28 Feb 2002 · continuation
Priority: DE 199 40 74031 Aug 1999
Published: US 2003/0158242 A121 Aug 2003
Granted: 20 Apr 2004
Term ends: Not estimatedThe source records don’t support an estimate.

Classification41 codes

C07D 275/06
Condensed with carbocyclic rings or ring systems: with hetero atoms directly attached to the ring sulfur atom
A61K 9/2081
Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets: with microcapsules or…
A61K 9/2846
Obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone: polyacrylates
A61K 9/5026
Organic macromolecular compounds: obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, polyacrylates

Family

PCT/EP00/07526Parent of this continuation · filed 3 Aug 2000
US 2003/0158242 A1Pre-grant publication · published 21 Aug 2003
US 6,723,343 B2This patent

From the US filing history. Foreign family members aren’t listed.

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