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US 6,720,454 B1Granted
Process for the cis-selective catalytic hydrogenation of cyclohexylidenamines
AssigneeCiba Specialty Chemicals Corporation
InventorsHeinz Steiner, Marc Thommen, Hans-Peter Jalett, Markus Benz
Life of this patent
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Abstract
The invention relates to a process for the cis-selective preparation of cyclic amines of the sertralin type by reductive alkylation of cyclic imines or their precursors and catalytic hydrogenation in the presence of copper-containing catalysts and in the presence of a protic solvent.
Claims5
A process for preparing compounds of the formula
- in which R1 and R2 are, independently of one another, hydrocarbon radicals and A are substituents and m is an integer from 0 to 4 which defines the number of substituents A, which comprises
- a) hydrogenating a cyclohexylidenamine of the formula:
- in which n is zero or 1, R1, R2, A and m are as defined above, in the presence of a copper-containing catalyst and in the presence of ethanol;
- or
- b) reacting a ketone of the formula:
- in which R2, A and m are as defined above, with a compound which introduces the group R1—N→(O)n, hydrogenating the imine or nitrone (II) obtainable as an intermediate in the presence of a copper-containing catalyst and in the presence of ethanol and isolating the cis compound (I).
3 more elements
Dependencies are inferred from the claim text.