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US 6,720,445 B2Granted
Acetyloxymethyl esters and methods for using the same
AssigneeBeacon Laboratories, Inc.
InventorsHsuan-Yin Lan-Hargest, Norbert L. Wiech
Life of this patent
Estimating the term…
Abstract
Novel acetyloxymethyl esters are disclosed. Methods of treating an illness, including cancer, hemological disorders and inherited metabolic disorders, and treating or ameliorating other conditions using these compounds are also disclosed. The compounds are effective in the inhibition of histone deacetylase.
Claims9
A compound having formula (1):
- wherein R is unsubstituted (C2-C10 alkenyl, substituted or unsubstituted C2-C10 alkynyl, or has the general formula (2):
- Z—(X)o—(R1)p—(R2)q— (2)
- wherein Z is selected from the group consisting of hydrogen, substituted or unsubstituted aryl, heteroaryl, cycloalkyl having the formula CnH2n−1, and alkoxyl;
- wherein n is 3 or greater;
- wherein X is S, O, C═O or CH2;
- wherein R1 is S, O, CH═CH or C≡C;
- wherein R2 is CH2, CH═CH or C≡C;
- and
- wherein o, p and q are the same or different and are each between 0 and 10, but when o is zero and R1 R2 is CH═CH or C≡C, Z is not hydrogen or alkoxy;
- but when o, p and q are zero, Z is not alkoxy.
7 more elements
A compound having the formula:
A compound having the formula:
A compound having the formula:
A compound having the formula (1):
- wherein R is unsubstituted C2-C10 alkenyl, C2-C10 alkynyl, or has the general formula (2):
- Z—(X)o—(R1)p—(R2)q— (2)
- wherein Z is selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, and cycloalkyl having the formula CnH2n-1;
- wherein n is 3 or greater;
- wherein X is S, O, C═O or CH2;
- wherein R1 is S, O, CH═CH or C≡C;
- wherein R2 is CH2, CH═CH or C≡C;
- and
- wherein o, p and q are the same or different and are each between 0 and 10.
6 more elements
Dependencies are inferred from the claim text.