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US 6,720,433 B2Granted
Ethylamine derivatives
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsHiroharu Matsuoka, Tsutomu Sato
Life of this patent
Estimating the term…
Abstract
Ethylamine derivatives that function as a motilin receptor antagonist and are useful as medicines are represented by the general formula (1): wherein R1 represents a phenyl group or the like, R2 represents a hydrogen atom and the like, R3 represents a hydrogen atom and the like, R4 represents a hydrogen atom and the like, R5 represents an alkyl group and the like, R7 represents a hydrogen atom and the like and R8 represents a heterocyclic ring and the like; or a hydrate or pharmaceutically acceptable salt thereof.
Claims15
A compound represented by the formula (1):
- wherein
- R1 is an optionally substituted aromatic ring;
- R2 is a hydrogen atom, an optionally substituted straight-chained or branched alkyl group having 1-3 carbon atoms, an amino group or a hydroxy group;
- R3 is a hydrogen atom, an optionally substituted straight-chained or branched alkyl group having 1-3 carbon atoms, an optionally substituted amino group or a hydroxy group;
- R4 is a hydrogen atom, a methyl group or an ethyl group;
- R5 is an optionally substituted straight-chained or branched alkyl group having 1-6 carbon atoms, a cycloalkyl group having 3-7 carbon atoms or an optionally substituted phenyl group;
- R6 is a hydrogen atom, a methyl group or an ethyl group;
- R7 is a hydrogen atom, an optionally substituted straight-chained or branched alkyl group having 1-3 carbon atoms or —CO—N(R9)R10;
- R8 is an optionally substituted 5-membered heterocyclic ring or an optionally substituted bicyclic ring system comprising a 5-membered heterocyclic ring;
- R11 is a hydroxy group or a halogen atom;
- R12, when R11 is a hydroxy group, represents a substituted straight-chained or branched alkyl group having 1-6 carbon atoms, a substituted straight-chained or branched alkenyl group having 2-6 carbon atoms, a substituted straight-chained or branched alkynyl group having 2-6 carbon atoms, a straight-chained or branched acyl group having 2-6 carbon atoms, a straight-chained or branched alkylsulfonyl group having 1-5 carbon atoms or an amino group mono- or di-substituted with a straight-chained or branched alkyl group having 1-5 carbon atoms, and R12, when R11 is a halogen atom, represents an optionally substituted straight-chained or branched alkyl group having 1-6 carbon atoms, an optionally substituted straight-chained or branched alkenyl group having 2-6 carbon atoms, an optionally substituted straight-chained or branched alkynyl group having 2-6 carbon atoms, a straight-chained or branched acyl group having 2-6 carbon atoms, a straight-chained or branched alkylsulfonyl group having 1-5 carbon atoms or an amino group mono- or di-substituted with a straight-chained or branched alkyl group having 1-5 carbon atoms;
- X is a carbonyl group or a methylene group;
- and
- Y is a carbonyl group or a methylene group;
- or a hydrate or pharmaceutically acceptable salt thereof.
12 more elements
Dependencies are inferred from the claim text.