Aminobenzoic acid derivatives
AssigneeTaisho Pharmaceutical Co., Ltd.
InventorsHisaya Wada, Hajime Asanuma, Tetsuo Takayama, Masakazu Sato, Takehiro Yamagishi, Masabumi Shibuya
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AssigneeTaisho Pharmaceutical Co., Ltd.
InventorsHisaya Wada, Hajime Asanuma, Tetsuo Takayama, Masakazu Sato, Takehiro Yamagishi, Masabumi Shibuya
Estimating the term…
Aminobenzoic acid derivatives represented by Formula (1) as follows: (wherein, R1 represents a hydrogen atom, a C1-6alkyl group, or the like; R2 represents a hydrogen atom, a C1-6alkyl group, or the like; R3 represents a C8-25alkyl group, or the like; R4 represents a hydrogen atom or a group represented by OR9 or CO2R10 (wherein R9 and R10 represent a hydrogen atom or a C1-6 alkyl group); A represents a group represented by S(O)qR15 (wherein q is 0, 1, or 2, R15 represents a C1-6alkyl group, a phenyl C1-3alkyl group, or a group represented by (CH2)mOR16 (wherein m is 2 or 3, and R16 represents a hydrogen atom or a methoxymethyl group), or the like; X represents O, a single bond, CH═CH, or a group represented by NR27 (wherein R27 represents a hydrogen atom or a t-butoxycarbonyl group); Y represents O, CONH, NHCO, or a group represented by NR28 (wherein R28 represents a hydrogen atom or a t-butoxycarbonyl group); and n is an integer of 0 to 15) or pharmaceutically acceptable salts of the same are employed as VEGF receptor antagonists, and in particular as therapeutic agents for the diseases in which VEGF is involved.
An aminobenzoic acid derivative represented by Formula (1) as follows:
Dependencies are inferred from the claim text.