Triamide-substituted heterobicyclic compounds

A compound of formula 1b

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is substituted at the 5 or 6 position of formula 1b and has the structure:
• or when R7 is phenyl, or phenyl-Z1— optionally substituted with one to five independently selected R12, R1 is (C1-C6)alkyl, (C3-C8)cycloalkyl, (C5-C10)bicycloalkyl, —(CRaRb)tO(C1-C6alkyl), —(CRaRb)tS(C1-C6alkyl), —(CRaRb)rC(O)R15, —(CRaRb)rR15, —SO2R15, aryl or —(CRaRb)q-aryl, wherein the cycloalkyl, or aryl moiety is optionally substituted with from one to five independently selected R16;
• m is an integer from 0 to 5;
• n is an integer from 0 to 3;
• p is an integer from 0 to 3;
• L is —C(O)N(R9)—;
• X1 is N(R4);
• X2 is C(Rc);
• R2, R6, R11, R12, R13 and R16 are each independently selected from halo, cyano, nitro, azido, amino, hydroxy, (C1-C6)alkyl, (C2-C6)alkoxy, methoxy, (C1-C6)alkoxy(C1-C6)alkyl, mono-, di- or tri-halo(C2-C6)alkyl, perfluoro(C2-C4)alkyl, trifluoromethyl, trifluoromethyl(C1-C5)alkyl, mono-, di- or tri-halo(C2-C6)alkoxy, trifluoromethyl(C1-C5)alkoxy, (C1-C6)alkylthio, hydroxy(C1-C6)alkyl, hydroxy, (C3-C8)cycloalkyl(CRaRb)q—, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkylamino-, (C1-C6) dialkylamino, amino(C1-C6)alkyl-, —(CRaRb)qNRaR14, —C(O)NRaR14, —NR14C(O)R15, —NR14OR15, —CH═NOR15, —NR14C(O)OR15, —NR14S(O)jR15, —C(O)R15, —C(S)R15, —C(O)OR15, —OC(O)R15, —SO2NRaR14, —S(O)jR15, or —(CRaRb)qS(O)jR15;
• each Ra and Rb is independently H or (C1-C6)alkyl;
• Rc is H or R11;
• each q is independently an integer from 0 to 6;
• each j is independently 0, 1 or 2;
• R3 is H, halo, (C1-C6)alkyl, or mono-, di- or tri-halo(C1-C6)alkyl;
• R4 is H, (C1-C6)alkyl, (C3-C8)cycloalkyl, —C(O)R15, —C(S)R15, —(CRaRb)tO(C1-C6alkyl), —(CRaRb)tS(C1-C6alkyl), —(CRaRb)rC(O)R15, —(CRaRb)rR15, —SO2R15 or —(CRaRb)q-phenyl, wherein the phenyl moiety is optionally substituted with from one to five independently selected R16;
• each r is independently an integer from 2 to 5;
• each t is independently an integer from 1 to 6;
• R5 and R9 are each independently H, (C1-C6)alkyl, (C3-C8)cycloalkyl, —C(O)R15, —C(S)R15, —(CRaRb)tO(C1-C6alkyl), —(CRaRb)tS(C1-C6alkyl), —(CRaRb)rC(O)R15, —(CRaRb)rR15 or —SO2R15;
• R6 is H, (C1-C6)alkyl, (C3-C8)cycloalkyl, —C(O)R15, —C(S)R15, —(CRaRb)qO(C1-C6alkyl), —(CRaRb)qS(C1-C6alkyl), —(CRaRb)rC(O)R15, —(CRaRb)rR15 or —SO2R15;
• R7 is (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, —(CRaRb)qO(C1-C6alkyl);
• —(CRaRb)qS(C1-C6alkyl);
• (C3-C8)cycloalkyl, —C(O)R15, —C(S)R15, —(CRaRb)rC(O)R15, —(CRaRb)rC(S)R15, —(CRaRb)rR15 or —SO2R15;
• or R7 is phenyl, or phenyl-Z1— optionally substituted with one to five independently selected R12;
• Z1 is —SO2— or —(CRaRb)v—;
• v is independently an interger from 1 to 6;
• wherein the alkyl, and cycloalkyl, moieties of the foregoing R6 group is optionally substituted independently with 1 to 3 substituents independently selected from halo, cyano, nitro, trifluoromethyl, trifluoromethoxy, azido, —OR15, —C(O)R15, —C(O)OR15, —OC(O)R15, —NR14C(O)R15, —C(O)NRaR14, —NRaR14, and —NR14OR15, C1-C6alkyl, C2-C6alkenyl, and C2-C6 alkynyl;
• and
• R10 is phenyl, or phenyl-Z2—, wherein the phenyl moiety is optionally substituted with one to five independently selected R13;
• Z2 is —S(O)j—, —O—, —(CRaRb)w—, or —(O)k(CRaRb)w(O)k(CRaRb)q—;
• w is independently an integer from 1 to 6;
• each k is independently 0 or 1;
• or R10 is OR17, wherein R17 is (C1-C8)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, mono-, di- or tri-halo(C2-C6)alkyl, perfluoro(C2-C4)alkyl, trifluoromethyl(C1-C5)alkyl, hydroxy(C1-C6)alkyl, (C3-C8)cycloalkyl(CRaRb)q—, (C2-C6)alkenyl, or (C2-C6)alkynyl;
• each R14 is independently H, (C1-C6)alkyl, (C3-C8)cycloalkyl, —C(O)R15, —C(S)R15, —(CRaRb)tO(C1-C6alkyl), —(CRaRb)tS(C1-C6alkyl), —(CRaRb)rC(O)R15, —(CRaRb)tR15 or —SO2R15;
• each R15 is independently H, (C1-C6)alkyl, (C3-C8)cycloalkyl, trifluoromethyl, trifluoromethyl(C1-C5)alkyl, wherein the alkyl, moieties of the foregoing R15 groups are independently optionally substituted with 1 to 3 substituents independently selected from C1-C6alkyl, C1-C6alkoxy, amino, hydroxy, halo, cyano, nitro, trifluoromethyl and trifluoromethoxy;
• and wherein any of the above “alkyl”, “alkenyl” or “alkynyl” moieties comprising a CH3 (methyl), CH2 (methylene), or CH (methine) group which is not substituted with halogen, SO or SO2, or attached to a N, O or S atom, optionally bears on said methyl, methylene or methine group a substituent selected from the group consisting of halo, —ORa, —SRa and —NRaRb.