Oxadiazole derivatives having anticancer effects
AssigneeShionogi & Co., Ltd.
InventorsTakayuki Yoshioka, Ryuji Maekawa, Fumihiko Watanabe
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Abstract
A pharmaceutical composition for treating or preventing cancer containing a compound of the general formula (I), a prodrug, a pharmaceutically acceptable salt, or a solvate thereof as an active ingredient: wherein R1 is hydroxy or the like; R2 is optionally substituted lower alkyl or the like; R3 is hydrogen or the like; R4 is optionally substituted arylene or the like; R5 is optionally substituted aryl or the like.
Claims8
A pharmaceutical composition for inhibiting matrix metalloproteinase containing a compound of the general formula (I), a prodrug, a pharmaceutically acceptable salt, or a solvate thereof as an active ingredient:
- wherein
- R1 is hydroxy;
- R2 is hydrogen, optionally substituted lower alkyl, optionally substituted aryl, or optionally substituted aralkyl;
- R3 is hydrogen, optionally substituted lower alkyl, optionally substituted aryl, or optionally substituted aralkyl;
- R4 is unsubstituted and
- R5 is optionally substituted thienyl.
A compound of the formula (I′):
- wherein
- R6 is hydroxy;
- R7 is hydrogen, methyl, isopropyl, isobutyl, benzyl, or indol-3-ylmethyl;
- R8 is hydrogen or optionally substituted lower alkyl;
- R9 is unsubstituted phenylene;
- R10 is optionally substituted thienyl;
- a prodrug, or a pharmaceutically acceptable salt, or a solvate thereof.
A compound of the following formula:
- a prodrug, or a pharmaceutically acceptable salt, or a solvate thereof.
A pharmaceutical composition for treating lung cancer containing a compound of the general formula (I), a prodrug, a pharmaceutically acceptable salt, or a solvate thereof as an active ingredient:
- wherein
- R1 is hydroxy;
- R2 is hydrogen, optionally substituted lower alkyl, optionally substituted aryl, or optionally substituted aralkyl;
- R3 is hydrogen, optionally substituted lower alkyl, optionally substituted aryl, or optionally substituted aralkyl;
- R4 is unsubstituted phenylene;
- and
- R5 is optionally substituted thienyl.
Dependencies are inferred from the claim text.