Lactone integrin antagonists

A compound of the Formula:

• wherein:
• y is zero;
• z is 1;
• A is C;
• R2, R3, and R4 are H, OH, or haloalkyl;
• Y is N—R1;
• R9 is H;
• R1 taken together with R8 forms a 4-12 membered dinitrogen containing heterocycle optionally substituted with one or more substituent selected from the group consisting of lower alkyl, hydroxy, keto, alkoxy, halogen, phenyl, amino, carboxyl or carboxyl ester, and fused phenyl;
• and
• R5, R6 and R7 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, phenyl, carboxyl derivatives, haloalkyl, cycloalkyl, monocyclic heterocycles optionally substituted with alkyl, halogen, haloalkyl, cyano, hydroxy, nitro, alkoxy, aryloxy, alkylsulfonyl, arylsulfonyl, sulfonamide, thio, alkylthio, carboxyl derivatives, amino, amido, about C1 to about C10 alkyl optionally substituted with one or more of halo, haloalkyl, hydroxy, alkoxy, aryloxy, thio, alkylthio, alkynyl, alkenyl, alkyl, arylthio, alkylsulfoxide, alkylsulfonyl, arylsulfoxide, arylsulfonyl, cyano, nitro, amino, alkylamino, dialkylamino, alkylsulfonamide, phenylsulfonamide, acylamide, carboxyl derivatives, sulfonamide, sulfonic acid, phosphonic acid derivatives, phosphinic acid derivatives, phenyl, phenylthio, phenylsulfoxide, or phenylsulfone all optionally substituted on the phenyl ring with halo, alkyl, haloalkyl, cyano, nitro, hydroxy, carboxyl derivatives, alkoxy, phenyloxy, amino, alkylamino, dialkylamino, amido, phenyl, fused phenyl, monocyclic heterocycles, and fused monocyclic heterocycles, monocyclic heterocyclicthio, monocyclic heterocycliesulfoxide, and monocyclic heterocyclic sulfone, which can be optionally substituted with halo, haloalkyl, nitro, hydroxy, alkoxy, fused phenyl, or alkyl, alkylcarbonyl, haloalkylcarbonyl, and phenylcarbonyl, phenyl optionally substituted in one or more positions with halo, haloalkyl, alkyl, alkoxy, phenyloxy, methylenedioxy, ethylenedioxy, alkylthio, haloalkylthio, thio, hydroxy, cyano, nitro, acyloxy, carboxyl derivatives, carboxyalkoxy, amido, acylamino, amino, alkylamino, dialkylamino, trifluoroalkoxy, trifluoromethylsulfonyl, alkylsulfonyl, sulfonic acid, sulfonamide, phenyl, fused phenyl, monocyclic heterocycles and fused monocyclic heterocycles.