Phenoxypropylamine compounds

A compound of the formula (I)

• wherein each symbol in the formula means as follows:
• a bond represented by a solid line and a dotted line shows a double bond or a single bond;
• X is a hydrogen atom, a hydroxy group, a C1-C8 alkoxy group, an acyloxy group or an oxo group;
• R1 is a group of the following formula
• wherein
• R5 is optionally substituted aryl group or optionally substituted aromatic heterocyclic group,
• Z is void or —CH2—, and
• R6 is hydrogen atom, hydroxy group, acetamido group, carboxyl group, alkoxycarbonyl group, cyano group or C1-C8 alkoxy group;
• R3 is a hydrogen atom, a C1-C18 alkyl group or a halogen atom;
• V is —O—;
• W is void;
• R7 is a C1-C4 hydroxyalkyl group, an acyl group, an optionally substituted saturated or unsaturated heterocyclic group, an optionally substituted fused heterocyclic group, a C1-C4 alkylsulfonyl group or the formula —Q—R9
• wherein
• Q is —C(═O)—, —C(═S)—, —CH2— or —S(═O)2—, and
• R9 is a group of the following formula
• or —NH—NH—R15
• wherein R10 and R11 are each independently hydrogen atom, C1-C18 alkyl group, optionally substituted aryl group, optionally substituted aralkyl group or alkoxy group, R12 is hydrogen atom, optionally substituted aryl group, C1-C18 alkyl group, C1-C8 alkoxy group or acyl group, and R15 is hydrogen atom, phenyl group, C1-C4 alkyl group, C1-C2 halogenated alkyl group, halogen atom, C2-C4 alkenyl group, C1-C4 hydroxyalkyl group, alkoxyalkyl group, alkyloxycarbonyl group, optionally substituted amino group, acetamido group, carboxyl group, acyl group, optionally substituted alkyloxy group, alkylthio group or cyano group;
• Ra, Rb and Rc are each independently a hydrogen atom, a C1-C18 alkyl group, a hydroxy group, a C1-C8 alkoxy group, a halogen atom, an acyl group, a nitro group or an amino group;
• an optically active compound thereof, a pharmaceutically acceptable salt thereof or a hydrate thereof.