Glycosylated analogs of fusidic acid
AssigneeUniversity of Michigan
InventorsRoeland Tuinman, Masato Koreeda, Brian Keith Shull
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Abstract
Novel analogs of fusidic acid are described with one or more carbohydrate units attached. Certain glycosylated analogs of fusidic acid have enhanced solubility properties in diluents or excipient of choice as compared to unmodified fusidic acid. Certain glycosylated analogs may be employed as chemotherapeutic agents and particular analogs may be useful for fighting anti-microbial infections.
Claims23
A composition comprising an O-glycoside analog of fusidic acid, wherein said fusidic acid has an acetate group at the C-16 position, a carboxylic acid at the C-21 position, and a cyclic carbohydrate attached via an oxygen atom at one or more positions selected from the group consisting of the C-3 position, the C-24 position, and the C-25 position.
A composition comprising a modified form of fusidic acid, wherein said fusidic acid has an acetate group at the C-16 position, and a protecting group at the C-11 position.
A composition comprising a modified form of fusidic acid, wherein said fusidic acid has an acetate group at the C-16 position, and a protecting group at one or more positions selected from the group consisting of the C-3 position, the C-11 position, and the C-21 position, and further comprising a cyclic carbohydrate at one or more positions selected from the group consisting of the C-3 position, the C-24 position, and the C-25 position.
Dependencies are inferred from the claim text.