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US 6,720,188 B2Granted
Methods and kits for the detection of arginine compounds
AssigneesFAL Diagnostics, Thomas W. Bell
InventorsRima Kaddurah-Daouk, Thomas W. Bell, Alisher B. Khasanov
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Abstract
Methods and kits for determine arginine compounds are discussed. The methods and kits of the invention can be used for the diagnosis of arginine compound associated disorders.
Claims35
A method for detecting arginine compounds in a body sample of a subject, comprising:
- contacting a body sample with an arginine compound recognizing substance which does not modify said arginine compound;
- and
- visually detecting the presence of said arginine compound by a change in color, wherein said arginine compound recognizing substance is of the formula:
- G(N)n(C)m (I)
- wherein
- G is a guanidinium recognizing moiety;
- N is an ammonium recognizing moiety;
- C is a carboxylate recognizing moiety;
- and
- n and m are each independently integers from 0 to 10, and wherein said arginine compound recognizing substance coordinates to said arginine compound, such that arginine compounds are detected.
7 more elements
A method for determining arginine compound levels in a body sample of a subject, comprising:
- contacting a body sample with a arginine recognizing substance;
- and
- analyzing the resulting mixture optically,
- such that arginine compound levels are determined, wherein said arginine recognizing substance is selected from the group consisting of:
- wherein X is hydrogen, alkyl, alkenyl, alkynyl, aryl, halogen, chromophore, or a fluorophore.
2 more elements
A method for determining asymmetric dimethyl arginine levels in a body sample of a subject, comprising:
- contacting a body sample with a asymmetric dimethyl arginine recognizing substance;
- and
- analyzing the resulting mixture optically,
- such that asymmetric dimethyl arginine compound levels are determined, wherein said asymmetric dimethyl arginine recognizing substance is selected from the group consisting of:
- wherein X is hydrogen, alkyl, alkenyl, alkynyl, aryl, halogen, chromophore, or a fluorophore.
2 more elements
Dependencies are inferred from the claim text.