Method of research for creating and testing novel catalysts, reactions and polymers
AssigneeSymyx Technologies, Inc.
InventorsHoward W. Turner, Adam Safir, Ralph B. Nielsen
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Abstract
A method and system for researching and developing and/or optimizing new catalysts and products in a combinatorial manner is disclosed. The method begins with starting components or a ligand library and provides methods of creating catalyst or product libraries, which are then tested in a reaction of interest. The system uses methods of robotic handling for moving libraries from station to station. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial catalyst libraries, but also offer significant advantages over conventional experimental methods as well.
Claims18
A method for researching for novel metal ligand catalysts, the method comprising:
- providing a parent ligand library comprising a plurality of chemically diverse member ligands in a spatially addressable format,
- forming a daughter library from the parent ligand library, the daughter ligand library being formed in a spatially addressable format on a common substrate by withdrawing aliquots of one or more member ligands from the parent ligand library and dispensing the withdrawn aliquots onto the common substrate,
- creating a metal-ligand complex library by combining one or more of the member ligands of the daughter library with one or more metal precursors on the common substrate, wherein the member ligand(s) and the metal precursor(s) are selected to provide the same metal-ligand complex in two separate spatially addressable regions of the common substrate from different member ligand and metal precursor combination(s), and
- screening at least a portion of the complex library in a reaction of interest.
Dependencies are inferred from the claim text.