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US 6,720,008 B2Granted
Composition and method for the encapsulation of water-soluble molecules into nanoparticles
AssigneePR Pharmaceuticals, Inc.
InventorStewart Dean Allison
Life of this patent
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Abstract
A method and composition for the encapsulation of hydrophilic molecules in submicron particles is disclosed. The particles are composed of a water-in-oil microemulsion surrounded by one or more biocompatible polymers.
Claims34
A method for encapsulating a water-soluble agent comprising:
- (a) forming a microemulsion containing the agent;
- (b) adding the microemulsion to a first solvent comprising one or more polymers, thereby forming a dispersion;
- (c) adding the dispersion to a second solvent which is a nonsolvent for one or more polymers;
- wherein following step (c), the microemulsion is encapsulated by the one or more polymers in the form of microparticles.
1 more element
A microparticle composition comprising a microemulsion containing a water-soluble agent and one or more polymers.
Dependencies are inferred from the claim text.