Process for producing wet ribavirin pellets

A process for producing ribavirin pellets, the process comprising:

• forming a mixture comprising (i) from about 35% to about 80% of ribavirin by weight, (ii) at least a filler, and (iii) at least a disintegrant;
• adding water in the range of 15-79% of the total mixture as a wetting agent to said mixture to form an extrudable mass;
• extruding said mass;
• forming pellets of said extruded mass;
• drying said pellets to form free flowing ribavirin pellets;
• and
• coating said dried pellets on an outside surface, resulting in a decreased rate of release of ribavirin during a given time span in comparison to the release under a condition without said coating.

A process for producing ribavirin pellets, the process comprising:

• mixing ribavirin, microcrystalline cellulose, and croscarmellose sodium to form a mixture;
• adding water in the range of 15-79% of the total mixture to said mixture to form a wet granulate of said mixture;
• spheronizing said wet granulate to form uniform sized pellets;
• drying said pellets to form free flowing ribavirin pellets;
• and
• coating said dried pellets on an outside surface, resulting in a decreased rate of release of ribavirin during a given time span in comparison to the release under a condition without said coating.

A process of forming flowable ribavirin particles, the process comprising:

• mixing ribavirin with at least one disintegrant, binder and filler to form a uniform mixture;
• adding water in the range of 15-79% of the total mixture to wet said uniform mixture;
• shaping said wet mixture into particles;
• and
• drying said particles to form free flowing ribavirin containing particles.