Tendon-inducing compositions
AssigneeGenetics Institute, Inc.
InventorsAnthony J. Celeste, John M. Wozney, Vicki A. Rosen, Neil M. Wolfman, Gerald H. Thomsen, Douglas A. Melton
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Abstract
Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.
Claims4
A purified Bone Morphogenetic Protein-12 related protein characterized by the ability to induce the formation of tendon/ligament-like tissue, wherein the protein is chosen from BMP-12, BMP-13, and MP52.
A pharmaceutical composition for tendon/ligament-like tissue healing and tissue repair, said composition comprising an effective amount of a Bone Morphogenetic Protein-12 related protein in a pharmaceutically acceptable vehicle, wherein the protein is chosen from SEQ ID NO:2, SEQ ID NO:4, and SEQ ID NO:26.
A pharmaceutical composition for tendon/ligament-like tissue repair, said composition comprising an effective amount of a Bone Morphogenetic Protein-12 related protein in a pharmaceutically acceptable vehicle, wherein the protein is chosen from BMP-12, BMP-13, and MP52.
A purified Bone Morphogenetic Protein-12 related protein characterized by the ability to induce the formation of tendon/ligament-like tissue, wherein the protein is chosen from SEQ ID NO:2, SEQ ID NO:4, and SEQ ID NO:26.
Dependencies are inferred from the claim text.