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AssigneeAmersham Biosciences AB
InventorsJohn Davis, Martin John Hofmann
Estimating the term…
An access valve suitable for controlling fluid flow into and out of a chromatography column has a central axially movable probe with a head acting as a spool valve in a barrel. Axial movement of the probe adjusts the valve between a fully open condition, in which both a first conduit extending through the probe and a second conduit defined around the probe are open to the column interior, a partly open condition in which a second sealing land on the probe closes the second conduit, and a fully closed position in which both conduits are closed. The three positions are useful for packing and unpacking chromatography media into and from the column. In the closed condition of the valve, the first and second conduits communicate with one another so that the valve interior can be cleaned while the column is operating.
Chromatography apparatus comprising a cylindrical column housing having a housing wall defining an enclosed bed space to contain a bed of particulate packing material in use and on access valve, said housing including end walls at opposite ends of the bed space, a said end wall comprising an inner fluid-permeable filter layer to retain said particulate packing material and an outer, impermeable end plate which supports the fluid-permeable filter layer from the outside, the supported filter layer having an inwardly concave form.
Chromatography apparatus comprising a cylindrical column housing whose housing wall defines an enclosed bed space to contain a bed of particulate packing material in use and an access valve, the housing wall including upper and lower end walls at opposite ends of the bed space, the lower end wall comprising an inner fluid-permeable filter layer to retain said particulate packing material while allowing the passage of liquid eluate during chromatography and an outer permeable end plate having support ribs which support the fluid-permeable filter layer from the outside, the filter layer being inwardly conically concave.
Chromatography apparatus comprising a cylindrical column housing whose housing wall defines an enclosed bed space to contain a bed of particulate packing material in use and an access valve, the housing wall including end walls at opposite ends of the bed space, a said end wall comprising
Dependencies are inferred from the claim text.