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US 6,719,868 B1Granted
Methods for fabricating microfluidic structures
AssigneePresident and Fellows of Harvard College
InventorsOlivier J. A. Schueller, David C. Duffy, John A. Rogers, Scott T. Brittain, George M. Whitesides
Life of this patent
Estimating the term…
Abstract
A system is provided for positioning separate portions of a sample in elongate, parallel channels of a sample chamber and to irradiate a sample in the chamber to create a diffraction pattern where the sample and chamber differ in refractive index. The system also can measure absorption of electromagnetic radiation by a sample in the chamber, and can measure the absorption simultaneously with measurement of diffraction by the sample.
Claims27
A method comprising:
- joining a pre-oxidized elastomeric surface to a second pre-oxidized surface, wherein the elastomeric surface and the second surface form an irreversible liquid-impermeable seal therebetween in a microfluidic structure.
A method comprising:
- applying an elastomeric surface to a second surface in the absence of auxiliary adhesive and at a temperature of between about 16° C. and about 27° C., wherein the elastomeric surface and the second surface bond to form an irreversible liquid-impermeable seal therebetween in a microfluidic structure.
A method comprising:
- joining a pre-oxidized elastomeric surface, comprising at least one microchannel formed in the elastomeric surface, to a second pre-oxidized surface, wherein the elastomeric surface and the second surface form an irreversible liquid-impermeable seal therebetween.
Dependencies are inferred from the claim text.