Resorbable posterior spinal fusion system
AssigneeMacroPore Biosurgery, Inc.
InventorsG. Bryan Cornwall, Gary Sohngen, Joseph M. Lane, Emre A. Tomin
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Abstract
Rolled resorbable membranes and methods for their application have been discovered. In accordance with one aspect of the present invention, rolled resorbable resorbable membranes are applied to the transverse processes of two or more vertebrae to facilitate fusion of the vertebrae.
Claims49
An implant for containing a bone-graft or growth material and facilitating posterior lateral fusion of at least two vertebrae following an in vivo surgical procedure, the implant having a pre-implant configuration which is defined as a configuration of the implant immediately before the implant is placed into contact with the at least two vertebrae, the implant comprising:
- a substantially-smooth membrane of resorbable polymer base material having a first substantially-smooth side, a second substantially-smooth side, and a perimeter edge joining the first substantially-smooth side to the second substantially-smooth side, wherein first and second points are disposed on opposing sides of the perimeter edge, the substantially-smooth membrane of resorbable polymer base material comprising a single layer of resorbable polymer base material between the first substantially-smooth side and the second substantially-smooth side, the single layer of resorbable polymer base material having a substantially uniform composition and being adapted to be rolled to bring the first point into proximity with the second point to thereby form a rolled layer of resorbable polymer base material;
- a plurality or apertures disposed in the single layer of resorbable polymer base material, the plurality of apertures being substantially uniformly distributed over at least a portion of both the first substantially-smooth side and the second substantially-smooth side of the single layer of resorbable polymer base material, each of the plurality of apertures of the implant when the implant is in the pre-implant configuration having a width which is between about 500 microns and about 3000 microns and which defines an isolated, non-intersecting, fluid-flow path from the first side to the second side;
- and
- a window formed in the substantially-smooth membrane of resorbable polymer base material, the window having a width that is greater than about 5 mm when the implant is in the pre-implant condition, the window being sized and shaped to accommodate a portion of a transverse process of one of the two vertebrae into the rolled layer of resorbable polymer base material when the rolled layer of resorbable polymer base material is placed into contact with the at least two vertebrae;
- wherein a thickness of the single layer of resorbable polymer base material, measured between the first substantially-smooth side and the second substantially-smooth side, is between about 0.5 mm and about 3 mm when the substantially-smooth membrane of resorbable polymer base material is in the pre-implant configuration;
- wherein each of the plurality of apertures of the substantially-smooth membrane of resorbable polymer base material immediately after implanting of the substantially-smooth membrane of resorbable polymer base material, has a diameter sufficient in size to allow a proliferation of vasculature and connective tissue cells, derived from adjacent soft tissues, to permeate through the aperture and substantially into a center of the rolled layer of resorbable polymer base material;
- wherein the implant comprises a configuration and strength sufficient to prevent prolapse of adjacent soft tissues into the center of the layer of resorbable polymer base material, when the single layer of resorbable polymer base material is rolled and placed into contact with the at least two vertebrae;
- and
- wherein the substantially-smooth membrane of resorbable base material is adapted to be resorbed into a mammalian body within a period of approximately 18 to 24 months from an initial implantation of the implant into the mammalian body.
An implant for containing a bone-graft or growth material and facilitating posterior lateral fusion of at least two vertebrae following an in vivo surgical procedure, the implant having a pre-implant configuration which is defined as a configuration of the implant immediately before the implant is placed into contact with the at least two vertebrae, the implant comprising:
- a substantially-smooth membrane of polymer base material having a first substantially-smooth side, a second substantially-smooth side, and a perimeter edge joining the first substantially-smooth side to the second substantially-smooth side, wherein first and second points are disposed on opposing sides of the perimeter edge, the substantially-smooth membrane of polymer base material comprising a layer of polymer base material between the first substantially-smooth side and the second substantially-smooth side, the layer of polymer base material having a substantially uniform composition and being adapted to be rolled to bring the first point into proximity with the second point to thereby form a rolled layer of resorbable polymer base material;
- and
- a window formed in the substantially-smooth membrane of polymer base material, the window having a width that is greater than about 5 mm when the implant is in the pre-implant condition, the window being sized and shaped to accommodate a portion of a transverse process of one of the two vertebrae into the rolled layer of polymer base material when the rolled layer of polymer base material is placed into contact with the at least two vertebrae;
- wherein a thickness of the layer of polymer base material, measured between the first substantially-smooth side and the second substantially-smooth side, is between about 0.5 mm and about 3 mm when the substantially-smooth membrane of polymer base material is in the pre-implant configuration.
An implant for containing a bone-graft material and facilitating posterior lateral fusion of at least two vertebrae following an in vivo surgical procedure, the implant having a pre-implant configuration which is defined as a configuration of the implant immediately before the implant is placed into contact with the at least two vertebrae, the implant comprising:
- a membrane of polymer base material having a first side, a second side and a perimeter edge joining the first side to the second side, the membrane of polymer base material being disposed between the first side and the second side, wherein the membrane of polymer base material is adapted to be rolled to bring two opposing points on the perimeter edge together;
- a first window which is sized and shaped, when the implant is rolled and placed into contact with the at least two vertebrae, to accommodate a portion of a transverse process of one of the two vertebrae into the rolled membrane, the first window having a width greater than about 5 mm;
- and
- a second window which is sized and shaped, when the implant is rolled and placed into contact with the at least two vertebrae, to accommodate a portion of a transverse process of the other of the two vertebrae, the second window having a width greater than about 5 mm.
A rolled implant suitable for containing a bone-graft material and facilitating posterior lateral fusion of at least two vertebrae following an in vivo surgical procedure, the rolled implant having a pre-implant configuration which is defined as a configuration of the rolled implant immediately before the rolled implant is placed into contact with the at least two vertebrae, the rolled implant comprising:
- a membrane of polymer base material having a first side and a second side, the membrane of polymer base material being disposed between the first side and the second side;
- and
- at least one window disposed in the rolled implant, the at least one window being sized and shaped to accommodate a portion of a transverse process of one of the two vertebrae into the rolled implant when the rolled implant is placed into contact with the at least two vertebrae, the window having a width greater than about 5 mm.
Dependencies are inferred from the claim text.