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US 6,719,751 B2Granted
Osmotic dosage form composed of an extruded polymer tube form
OwnerLiang-Chang Dong, Patrick S.-L. Wong +3inventors
InventorsLiang-Chang Dong, Patrick S.-L. Wong, Atul Devdatt Ayer, Padmaja Shivanand, Michael A. DesJardin
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Abstract
A dosage form manufactured from an extruded polymer tube and method for manufacturing the dosage form are disclosed. The dosage form is preferably an osmotic dosage form and includes a therapeutic agent and an expandable composition contained within the lumen of the extruded polymer tube.
Claims21
A dosage form comprising:
- an extruded polymer tube comprised of a polymer that is permeable to passage of biological fluids to form a semi-permeable outer tube wall, the polymer tube having an internal compartment and two open ends for communication between the internal compartment and an environment of use;
- and
- disposed within the internal compartment (i) a therapeutic agent and (ii) an expandable composition capable of absorbing the biological fluid to expand and force the therapeutic agent out at least one of the ends into the environment of use.
A process for manufacturing a dosage form comprising:
- extruding a polymer into a tube form having an internal compartment and first and second open ends, the polymer forming a tube having a semipermeable wall that is permeable to passage of biological fluids;
- and
- introducing into the internal compartment (i) a therapeutic agent and (ii) an expandable composition capable of absorbing biological fluid from a surrounding environment of use to expand and force the therapeutic agent out at least one of the ends into the environment of use.
Dependencies are inferred from the claim text.