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US 6,716,984 B2Granted
Polymer-supported synthesis of heteroatom bidentate ligands for catalysis
AssigneeE. I. Du Pont de Nemours and Company
InventorGeorge Y. Li
Life of this patent
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Abstract
The invention relates to the combinatorial approaches to the preparation of novel polymer-supported heteroatom bidentate (PN, PO, PS) ligand libraries and the corresponding free compounds after cleavage from the supports. These compounds are useful as novel ligands in the preparation of metal-containing catalysts.
Claims6
The process to prepare a supported phosphine compound of the structure of Formula 1 A:
- the process comprising the steps of:
- a) contacting a phosphine of the formula XPR1R2, wherein X is a halogen, with the solid support, resulting in the P in the phosphine attached indirectly or directly to the solid support via a covalent bond, and
- b) optionally, replacing one or more of R1 or R2 with any other R1 or R2 respectively, wherein:
- SS is a polymer solid support;
- R1 is selected from the group consisting of halogen, hydrocarbyl, substituted hydrocarbyl, heterocyclic and substituted heterocyclic;
- R2 is selected from the group consisting of halogen, cyclic hydrocarbyl, substituted cyclic hydrocarbyl, heterocyclic and substituted heterocyclic;
- Z is a divalent or trivalent attaching group covalently attached to at least one phosphorus in the phosphine, selected from the group consisting of hydrocarbylene, substituted hydrocarbylene, —O—, —S—, and —NQ—, where Q is selected from the group consisting of an optionally-substituted hydrocarbyl and halogen;
- and
- L is a divalent linking group covalently attached to Z and to SS, selected from the group consisting of optionally-substituted chains of from 1 to 12 linear, branched, and cyclic carbon atoms.
6 more elements
The supported phosphine compound of the structure of Formula 1A:
- wherein:
- SS is a polymer solid support;
- R1 is selected from the group consisting of halogen, hydrocarbyl, substituted hydrocarbyl, heterocyclic and substituted heterocyclic;
- R2 is selected from the group consisting of halogen, cyclic hydrocarbyl, substituted cyclic hydrocarbyl, heterocyclic and substituted heterocyclic;
- Z is a divalent or trivalent attaching group covalently attached to at least one phosphorus in the phosphine, selected from the group consisting of hydrocarbylene, substituted hydrocarbylene, —O—, —S—, and —NQ—, where Q is selected from the group consisting of an optionally-substituted hydrocarbyl and halogen;
- and
- L is a divalent linking group covalently attached to Z and to SS, selected from the group consisting of optionally-substituted chains of from 1 to 12 linear, branched, and cyclic carbon atoms.
4 more elements
Dependencies are inferred from the claim text.