Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis
AssigneeHouse Ear Institute
InventorsDavid J. Lim, Haa-Yung Lee, Paul Webster, Ali Andalibi, Jian-Dong Li, Tomas Ganz
Life of this patent
Estimating the term…
Abstract
Disclosed herein is a method for the treatment of otitis media and paranasal sinusitis using human defensins, lysozyme and/or lactoferrin as a new class of non-antibiotic antimicrobials. From studies of otitis media and paranasal sinusitis, it was observed that certain innate immune modulators were important in the bodies response to the infection. Therefore, these innate immune modulators, lysozyme, lactoferrin and defensins, were tested for use as a non-antibiotic treatment for infection, particularly infections such as otitis media and sinusitis.
Claims16
A method for the treatment of microbial infections of ears and sinuses in a human, comprising administering to said human a pharmaceutical preparation comprising lactoferrins, lysozyme and defensins in an amount effective for a reduction of said microbial infection, wherein said microbial infection comprises a bacteria selected from the group consisting of Streptococcus pneumoniae, non-typeable Haemophilus influenzae (NTHi), and Moraxella catarrhalis, said pharmaceutical preparation further comprising a pharmaceutically acceptable carrier, wherein said carrier has a concentration of sodium chloride salt below about 100 mM.
Dependencies are inferred from the claim text.