Method and assembly for fluid transfer

A drug bottle for use in a fluid transfer assembly, the drug bottle having a neck with an opening covered by a closure and a neck element irreversibly coupled to the neck by means of locking members;

• the fluid transfer assembly being of a type comprising a bottle connector having a hollow needle for penetrating the closure when establishing a fluid transfer line in the fluid transfer assembly;
• the locking members also being able to irreversibly couple to the connector;
• wherein the neck element further comprises guiding members for participating in directing the hollow needle of the connector to penetrate the closure at a predetermined angle when establishing the fluid transfer line;
• and
• the locking members of the neck element further comprise at least one of a flexible tongue having a protrusion for entering an aperture of the connector and a flexible tongue having an aperture for receiving a protrusion of the connector.

A drug bottle for use in a fluid transfer assembly, the drug bottle having a neck with an opening covered by a closure and a neck element irreversibly coupled to the neck by means of locking members;

• the fluid transfer assembly being of a type comprising a bottle connector having a hollow needle for penetrating the closure when establishing a fluid transfer line in the fluid transfer assembly;
• the locking members also being able to irreversibly couple to the connector;
• wherein the neck element further comprises guiding members for participating in directing the hollow needle of the connector to penetrate the closure at a predetermined angle when establishing the fluid transfer line;
• the neck element further comprising a flexible polymer material ring, an inside, an outside, and a bottle end;
• wherein at least one of the locking members is engageable on the inside and at least one of the locking members is engageable on the outside on one or more flexible tongues;
• and
• wherein the flexible tongues are located at the bottle end and the neck element further comprises axially extending guide grooves along the outside intended to interact with corresponding guide ribs inside the connector.

An arrangement for utilization in a fluid transfer assembly in which a bottle connector, a drug bottle with a neck having an opening covered by a closure, and the connector having a hollow needle for penetrating the closure when establishing a fluid transfer line in the fluid transfer assembly, the arrangement comprising:

• a neck element having locking members adapted for irreversible coupling the neck and the connector;
• and
• said neck element further comprising guiding members adapted for directing the hollow needle of the connector, in penetration of the closure, at a predetermined angle when establishing the fluid transfer line;
• a connector having a proximate end having first locking members for said irreversible coupling to the neck and a distal end having second locking members for coupling to the fluid transfer device;
• and
• the fluid transfer device having a cannula, and the distal end exposing a membrane through which the cannula, via the hollow needle, can penetrate the closure to establish the fluid transfer line between the bottle and the fluid transfer device after having accomplished the irreversible coupling;
• the neck element further comprising third locking members for irreversible coupling to said neck before establishing said fluid transfer line, and fourth locking members for irreversible coupling to said first locking members;
• and
• the guiding members of said neck element being designed to direct the hollow needle to penetrate the closure at an angle between about 80° and about 100° relative thereto when establishing the fluid transfer line.

A fluid transfer assembly comprising:

• a drug bottle having a neck with an opening covered by a closure;
• a bottle connector having a hollow needle for penetrating said closure when establishing a fluid transfer line in said fluid transfer assembly;
• a neck element having locking members for irreversible coupling to said neck and to said connector;
• said neck element and said connector further comprising interacting guiding members for directing said hollow needle to penetrate said closure at a predetermined angle when establishing said fluid transfer line;
• first locking members at a proximate end of said connector for said irreversible coupling to said neck,
• second locking members at a distal end of said connector for coupling to a fluid transfer device, said fluid transfer device having a cannula, and said distal end exposing a membrane through which said cannula, via said hollow needle, can penetrate said closure in order to establish said fluid transfer line between said bottle and said fluid transfer device after having accomplished said irreversible coupling;
• said neck element further comprising third locking members for said irreversible coupling to said neck before establishing said fluid transfer line;
• fourth locking members for irreversible coupling to said first locking members;
• and
• wherein said guiding members are designed for directing said hollow needle to penetrate said closure at an angle between about 80° and about 100° when establishing said fluid transfer line.

A fluid transfer assembly comprising:

• a drug bottle having a neck with an opening covered by a closure;
• a bottle connector having a hollow needle for penetrating said closure when establishing a fluid transfer line in said fluid transfer assembly;
• a neck element having locking members for irreversible coupling to said neck and to said connector, said locking members of said neck element further comprising at least one of a flexible tongue having a protrusion for entering an aperture of said connector and a flexible tongue having an aperture for receiving a protrusion of said connector;
• and
• said neck element and said connector further comprising interacting guiding members for directing said hollow needle to penetrate said closure at a predetermined angle when establishing said fluid transfer line.

A method for fluid transfer using a bottle connector and a drug bottle, the method comprising the steps of:

• providing the bottle a neck with an opening covered by a closure;
• providing the connector with a hollow needle;
• penetrating the closure with the hollow needle when establishing a fluid transfer line;
• providing a neck element having locking members and guiding members;
• and
• first irreversibly coupling the neck element to the neck and then to the connector by means of the locking members, and therebetween directing the hollow needle to penetrate the closure at a predetermined angle with the aid of the guiding members of the neck element when establishing the fluid transfer line;
• providing at least one first locking member having a flexible tongue forming an aperture and the neck element providing at least one fourth locking member comprising a flexible tongue having a protrusion;
• and
• wherein the irreversible coupling between the neck element and the connector is created by making the protrusion enter the aperture.

A method for fluid transfer using a bottle connector and a drug bottle, the method comprising the steps of:

• providing the bottle a neck with an opening covered by a closure;
• providing the connector with a hollow needle;
• penetrating the closure with the hollow needle when establishing a fluid transfer line;
• providing a neck element having locking members and guiding members;
• first irreversibly coupling the neck element to the neck and then to the connector by means of the locking members, and therebetween directing the hollow needle to penetrate the closure at a predetermined angle with the aid of the guiding members of the neck element when establishing the fluid transfer line;
• and
• providing the neck elements with one or more fourth locking members comprising a flexible tongue forming an aperture and providing the connector with one or more first locking members comprising a flexible tongue having a protrusion, wherein the irreversible coupling between the neck element and the connector is created by making the protrusion enter the aperture.

A method for fluid transfer using a bottle connector and a drug bottle, the method comprising the steps of:

• providing the bottle a neck with an opening covered by a closure;
• providing the connector with a hollow needle;
• penetrating the closure with the hollow needle when establishing a fluid transfer line;
• providing a neck element having locking members and guiding members;
• first irreversibly coupling the neck element to the neck and then to the connector by means of the locking members, and therebetween directing the hollow needle to penetrate the closure at a predetermined angle with the aid of the guiding members of the neck element when establishing the fluid transfer line;
• wherein the neck element further comprises a flexible polymer material ring, an inside and outside, one or more third locking members on the inside and at least one fourth locking member on the outside on flexible tongues at a bottle end, and the ring further comprising axially extending guide grooves along the outside and the connector further comprising guide ribs on its inside;
• and
• making the guide grooves interact with the guide ribs.

A method for fluid transfer using a bottle connector and a drug bottle, the method comprising the steps of:

• providing the bottle a neck with an opening covered by a closure;
• providing the connector with a hollow needle;
• penetrating the closure with the hollow needle when establishing a fluid transfer line;
• providing a neck element having locking members and guiding members;
• first irreversibly coupling the neck element to the neck and then to the connector by means of the locking members, and therebetween directing the hollow needle to penetrate the closure at a predetermined angle with the aid of the guiding members of the neck element when establishing the fluid transfer line;
• providing a fluid transfer channel within the hollow needle of the connector;
• providing a pressure compensator comprising a flexible container and a gas channel within the hollow needle;
• and
• transporting gas from the bottle to the flexible container or vice versa in order to allow fluid to be transferred via the fluid transfer channel, wherein the gas channel includes a filter preventing liquid passage into the flexible container.