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US 6,713,664 B2Granted
Fatty acid elongase 3-ketoacyl CoA synthase polypeptides
AssigneeMiami University
InventorsJan G. Jaworski, Brenda J. Blacklock
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Abstract
Elongase KCS polypeptides with altered substrate specificity and/or catalytic activity are disclosed. Such elongase KCS polypeptides are effective for producing very long chain fatty acids (VLCFA) fatty acids. Also disclosed are nucleic acids encoding elongase KCS polypeptides, and yeast and plants expressing these polypeptides.
Claims10
An isolated nucleic acid encoding a polypeptide, said polypeptide comprising in the amino-terminal to carboxy-terminal direction:
- (a) a first polypeptide segment, wherein said first polypeptide segment has membrane anchoring properties;
- joined to
- (b) a second polypeptide segment having a sequence selected from the group consisting of residues 75-114 of SEQ ID NO:12 and residues 75-114 of SEQ ID NO:14;
- joined to
- (c) a third polypeptide segment having at least 40% sequence identity to residues 115-506 of SEQ ID NO:4.
2 more elements
Dependencies are inferred from the claim text.