Back to results
US 6,713,625 B2Granted
Process for the preparation of cefditoren using the thioester of thiazolylacetic acid
AssigneeOrchid Chemicals & Pharmaceuticals Limited
InventorsPandurang Balwant Deshpande, Parven Kumar Luthra
Life of this patent
Estimating the term…
Abstract
The present invention provides a process for the preparation of Cefditoren of the formula (I) which comprises acylating 7-amino-cephem carboxylic acids of the general formula (IV) where R3 is hydrogen or trimethylsilyl with thioester derivatives of the formula (II) wherein R1 represents C1-C4 alkyl or phenyl in an organic solvent in the presence of an organic base at a temperature in the range of −10° C. to 30° C.
Claims10
A process for the preparation of Cefditoren of formula (I)
- which comprises acylating a compound of formula (IV)
- wherein, R3 is hydrogen or trimethylsilyl, with a compound of formula (II)
- wherein R1 represents C1-C4 alkyl or phenyl, in the presence of an organic solvent, and an organic base at a temperature in the range of −10° C. to 30° C.
Dependencies are inferred from the claim text.