Tetraphosphonate bicyclic trisanhydrides
AssigneePharmasset, Inc.
InventorsKrzysztof W. Pankiewicz, Krystyna Lesiak, Kyoichi A. Watanabe
Life of this patent
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Abstract
Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biologically active compounds, and the compounds which may be synthesized from such intermediates.
Claims42
A compound of formula I
- wherein:
- a) Z is 2′,3′-O-isopropylideneadenosine-5′-yl;
- and
- b) Z1 is aralkyl.
A compound of formula I
- wherein:
- a) Z is a nucleoside;
- and
- b) Z1 is aralkyl.
A compound of formula I
- wherein:
- a) Z is a nucleoside;
- b) Z1 is benzamide riboside-5′-yl;
- and
- c) X is CH2, CF2, or CHF.
P1-(adenosine-5′-yl)-P2-(benzamide riboside-5′-yl)methylenebis(phosphonate).
P1-(adenosine-5′-yl)-P2-(benzamide riboside-5′-yl)fluoromethylenbis(phosphonate).
P1-(adenosine-5′-yl)-P2-(benzamide riboside-5′-yl)difluoromethylenebis(phosphonate).
A compound of formula I
- wherein:
- a) Z is a nucleoside;
- b) Z1 is a riboflavin residue;
- and
- c) X is CH2, CF2, or CHF.
P1-(adenosin-5′-yl)-P2-(riboflavin-5′-yl)methylenebis(phosphonate).
A compound of formula I
- wherein:
- a) Z is a nucleoside;
- b) Z1 is 1,2-diacyl-glycer-3-yl;
- and
- c) X is CH2, CF2, or CHF.
P1-(2′,3′-O-isopropylidenecytidine-5′-yl)-P2-(1,2-diacyl-glycer-3-yl)methylenebis(phosphonate).
P1-(cytidine-5′-yl)-P2-(1,2-diacyl-glycer-3-yl)methylenebis(phosphonate).
P1-(cytidine-5′-yl)-P2-(1,2-diacyl-sn-glycer-3-yl)methylenebis(phosphonate).
P1-(cytidine-5′-yl)-P2-(1,2-dipalmitoyl-sn-glycer-3-yl)methylenebis(phosphonate).
A compound of formula I
- wherein:
- a) Z is a nucleoside;
- b) Z1 is N-acetylamino(ethyl);
- and
- c) X is CH2, CF2, or CHF.
P1-(2′,3′-O-isopropylidenecytidine-5′-yl)-P2-[(N-acetylamino)ethyl]methylenebis(phosphonate).
P1-(cytidine-5′-yl)-P2-[(N-acetylamino)ethyl]methylenebis(phosphonate).
A compound of formula I
- wherein:
- a) Z is adenosine-5′-yl;
- b) Z1 is aralkyl;
- and
- c) X is CH2, CHF, or CF2.
A compound of formula I
- wherein:
- a) Z is a nucleoside;
- b) Z1 is the residue of a mycophenol;
- and
- c) X is CH2, CHF, or CF2.
Dependencies are inferred from the claim text.