High affinity TGFβ nucleic acid ligands and inhibitors
AssigneeGilead Sciences, Inc.
InventorsNikos Pagratis, Michael Lochrie, Larry Gold
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Abstract
Methods are described for the identification and preparation of high-affinity nucleic acid ligands to TGFβ2. Included in the invention are specific RNA ligands to TGFβ2 identified by the SELEX method. Also included are RNA ligands that inhibit the interaction of TGFβ2 with its receptor.
Claims14
A purified and isolated non-naturally occurring RNA ligand to transforming growth factor β1 (TGFβ1) wherein said ligand is selected from the group consisting of the sequences set forth in Table 22 (SEQ ID NOS:194-215).
A complex comprised of a TGFβ2 nucleic acid ligand, and a non-immunogenic, high molecular weight compound or lipophilic compound, wherein said ligand is selected from the group consisting of the sequences set forth in Tables 5, 7, 8, 11, 13, 14, 16-19, and FIG. 9 (SEQ ID NOS:21-121 and 128-193).
Dependencies are inferred from the claim text.