Monoclonal antibodies to type I interferon receptor
AssigneeGenentech, Inc.
InventorsAnan Chuntharapai, Kyung Jin Kim, Richard B. Love, Ji Lu
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Abstract
Anti-IFNAR1 monoclonal antibodies with neutralizing activities against the anti-viral cytopathic effects of various type I interferons are provided.
Claims18
An anti-IFNAR1 monoclonal antibody that inhibits the anti-viral activity of a first type I interferon selected from the group consisting of IFN-α1, IFN-α2/1, IFN-α2, IFN-α5, and IFN-α8 and does not inhibit the anti-viral activity of a second type I interferon selected from the group consisting of IFN-α1, IFN-α2/1, IFN-α5, and IFN-β.
An anti-IFNAR1 monoclonal antibody that inhibits a type I interferon selected from the group consisting of IFN-α1, IFN-α2/1, IFN-α2, IFN-α5, and IFN-α8 from inducing formation of an IFN-stimulating response element binding protein but does not inhibit the anti-viral activity of a second type I interferon selected from the group consisting of IFN-α1, IFN-α2/1, IFN-α5, and IFN-β.
Dependencies are inferred from the claim text.