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US 6,713,606 B1Granted
Conjugates of soluble peptidic compounds with membrane-binding agents
AssigneeAdProTech Limited
InventorsRichard Anthony Godwin Smith, Ian Dodd, Danuta Ewa Irena Mossakowska
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Abstract
The present invention provides, among other things, soluble derivatives of soluble polypeptides that incorporate membrane binding elements. Methods of making these soluble derivatives, and methods of using these soluble derivatives also are provided.
Claims14
A soluble compound that is directed to an outer membrane of a cell, wherein the soluble compound comprises:
- (1) a soluble polypeptide that inhibits complement;
- and
- (2) a membrane localization reagent, wherein the membrane localization reagent is soluble and comprises:
- (a) at least one lipophilic binding element comprising aliphatic acyl groups;
- (b) a hydrophilic peptide binding element comprising basic amino acids, wherein the hydrophilic binding element is bound to the lipophilic element;
- and
- (c) a linker that covalently binds a therapeutic agent to the hydrophilic peptide binding element of the membrane localization reagent to form the soluble compound.
4 more elements
A pharmaceutical composition that is directed to an outer membrane of a cell, comprising
- (1) a soluble polypeptide that inhibits complement;
- (2) a membrane localization reagent, wherein the membrane localization reagent is soluble and comprises:
- (a) at least one lipophilic binding element comprising aliphatic acyl groups;
- (b) a hydrophilic peptide binding element comprising basic amino acids, wherein the hydrophilic binding element is bound to the lipophilic element;
- and
- (c) a linker that covalently binds a therapeutic agent to the hydrophilic peptide binding element of the membrane localization reagent to form the soluble compound;
- and
- (3) a pharmaceutically acceptable carrier or excipient.
5 more elements
Dependencies are inferred from the claim text.