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US 6,713,568 B1Granted
Composition and process for preparing biocompatible polymer coatings
AssigneeSciMed Life Systems, Inc.
InventorsBirendra K. Patnaik, Richard J. Zdrahala
Life of this patent
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Abstract
Disclosed are bio-active polymer coatings. More particularly, improved bio-active polymer coating are disclosed which include bio-active molecules attached to polymer backbones via spacers having reactive nitrogen groups. Also disclosed are novel reaction schemes for producing same.
Claims13
A method for preparing a bio-active coating comprising:
- providing a prepolymer backbone having a reactive functionality selected from the group consisting essentially of saturated and unsaturated carboxylic acid functional groups and mixtures thereof;
- b) forming a pendent group off of said prepolymer backbone by reacting a carbon atom of said reactive functionality with a spacer, said spacer having reactive nitrogen groups, wherein said carbon atom forms a covalent bond with a reactive nitrogen group of said spacer in the presence of a first dehydrating agent;
- and
- c) reacting an unreacted nitrogen group of said spacer with a bio-active agent in the presence of a second dehydrating agent to covalently bond said bio-active agent to said pendent group.
1 more element
A method for preparing a bio-compatible coating comprising:
- a) providing a prepolymer backbone having reactive unsaturated carboxylic acid functional group;
- b) reacting said unsaturated carboxylic acid functional group with a spacer compound having at least two reactive nitrogen atoms, and
- c) reacting a nitrogen atom of said spacer with a bio-active agent to bond said bio-active agent to said pendent group.
Dependencies are inferred from the claim text.