Nanocapsules and method of production thereof
AssigneeNovosom AG
InventorSteffen Panzner
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Abstract
The invention relates to nanocapsules with a size ranging between 50 nm and 10 μm diameter whose envelope layer consists of at least two different, cross-linked polymers P1 and P2. Optionally, a lipid layer may be present underneath said envelope layer. The inventive nanocapsules are produced by covalently cross-linking at least two different water-soluble polymers P1 and P2 on the surface of liposomes. Optionally, the liposomes are dissolved once the polymers are cross-linked. The inventive nanocapsules can carry biologically active compounds.
Claims15
A method of producing nanocapsules having a diameter of from 50 nm to 10 μm, diameter characterized in that liposomes are produced which are coated with a polymer P1 by binding the polymer P1 to the liposome surface in an aqueous solution, and the coated polymer P1 then is covalently crosslinked in an aqueous solution with a polymer P2 which is different from polymer P1, and additional polymer layers are optionally coated by crosslinking.
Nanocapsules having a diameter of from 50 nm to 10 μm, characterized in that the coat layer thereof is comprised of at least two different polymers P1 and P2 crosslinked with each other.
Dependencies are inferred from the claim text.