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US 6,713,505 B2Granted
spla2 inhibitors
AssigneeEli Lilly and Company
InventorsMichael Dean Kinnick, Ho-Shen Lin, Michael John Martinelli, John Michael Morin, Michael Enrico Richett
Life of this patent
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Abstract
A class of novel benzo(b)thiophene is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
Claims8
A benzo(b)thiophene compound represented by the formula (I), or a pharmaceutically acceptable salt or solvate thereof;
- wherein;
- R2 is hydrogen, or a group containing 1 to 4 non-hydrogen atoms plus any required hydrogen atoms;
- R3 is —(L3)—Z, where —(L3)— is a divalent linker group selected from a bond or a divalent group selected from:
- and Z is selected from a group represented by the formulae,
- R4 is the group —(Lc)-acylamino acid group), wherein —(Lc)—, is an acylamino acid linker having an acylamino acid linker length of 1 to 8;
- R5 is selected from hydrogen,
- R6 and R7 are selected from hydrogen.
4 more elements
A benzo(b)thiophene compound represented by the formulae (C17) or (C18);
- or pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.