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US 6,713,495 B1Granted
Magnesium omeprazole
AssigneeBernard Charles Sherman
InventorBernard Charles Sherman
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Abstract
Improved process to produce magnesium omeprazole substantially amorphous with pharmaceutically acceptable low level of methanol and solid pharmaceutical compositions.
Claims13
A process of producing magnesium omeprazole, said process comprising the steps of:
- (i) reacting magnesium with a lower alcohol to produce magnesium alkoxide in solution in the lower alcohol as solvent,
- (ii) adding omeprazole to the solution, the amount of omeprazole being about 2 moles per mole of magnesium, and
- (iii) flash-evaporating the solvent yielding magnesium omeprazole having a degree of crystallinity of under 67% by weight and having a residual organic solvent content of less than 7% by weight.
Magnesium omeprazole having a degree of crystallinity of under 67% by weight and having a residual organic solvent content of less than 7% by weight.
Dependencies are inferred from the claim text.