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US 6,713,483 B1Granted
[1,2,3]-triazolo[4,5-d] pyrimidine compounds
AssigneeAstraZeneca AB
InventorsSimon Guile, Brian Springthorpe
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Abstract
The invention provides [1,2,3]-triazolo[4,5-d]pyrimidine analogue compounds of formula (I) The invention is also directed to pharmaceutical compositions containing the compounds, processes for the preparation of the compounds and methods of treatment employing the compounds.
Claims20
A compound of formula (I):
- wherein:
- R1 is OR5 or CH2R6;
- R2 is alkyl C1-6 or haloalkyl C1-6;
- R3 is cycloalkyl C3-6, optionally substituted by R7;
- R4 is alkyl C1-6;
- R5 is H or alkyl C1-6, optionally substituted by OH;
- R6 is OH, N3, or NHR8;
- R7 is phenyl, optionally substituted by one or more groups selected from alkyl C1-6, halogen, and OR10;
- R8 is H, alkyl C1-6, or COR9;
- R9 is alkyl C1-6;
- R10 is alkyl C1-6;
- or a pharmaceutically acceptable salt or solvate thereof,
- or a solvate of such a salt.
10 more elements
Dependencies are inferred from the claim text.