6-O-carbamate-11,12-lacto-ketolide antimicrobials

A compound of Formula 1:

• wherein
• R1 and R2 are independently selected from hydrogen, optionally substituted C1-C8-alkyl, optionally substituted —CH2—C2-8 alkenyl, and optionally substituted —CH2—C2-8 alkynyl, wherein the substituents are selected from the group consisting of C1-C8 alkyl, —CH2—C2-8 alkenyl, —CH2—C2-8 alkynyl, C3-C8 cycloalkyl, aryl, heteroaryl, substituted aryl, substituted heteroaryl, hydroxy, and C1-8alkoxy;
• R3 is selected from hydrogen, OR4, SR4 and NR5R6, wherein R4, R5, and R6 are independently selected from the group consisting of C1-8alkyl, C3-8alkenyl, and C3-8 alkynyl, said C1-8alkyl, C3-8alkenyl, and C3-8alkynyl being optionally substituted with one or more substituents selected from the group consisting of aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxy, and C1-6alkoxy;
• R7 is hydrogen or a hydroxy protecting group;
• and
• R8 is selected from hydrogen, alkyl, C2-C10-alkenyl, C2-C10-alkynyl, aryl, heteroaryl, heterocyclo, aryl(C1-C10)alkyl, aryl(C2-C10)alkenyl, aryl(C2-C10)alkynyl, heterocyclo(C1-C10)alkyl, heterocyclo(C2-C10)alkenyl, and heterocyclo(C2-C10)alkynyl, C3-C6-cycloalkyl, C5-C8-cycloalkenyl, alkoxyalkyl containing 1-6 carbon atoms in each alkyl or alkoxy group, and alkylthioalkyl containing 1-6 carbon atoms in each alkyl or thioalkyl group;
• or an optical isomer, enantiomer, diastereomer, racemate or racemic mixture thereof, or a pharmaceutically acceptable salt, esters or pro-drugs thereof.