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US 6,713,450 B2Granted
Synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid β for induction of an immune response to amyloid β and amyloid deposits
AssigneeNew York University
InventorsBlas Frangione, Thomas Wisniewski, Einar M. Sigurdsson
Life of this patent
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Abstract
The present invention relates to synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid β which can be used alone or conjugated to an immunostimulatory molecule in an immunizing composition for inducing an immune response to amyloid β peptides and amyloid deposits.
Claims30
An isolated peptide comprising the amino acid sequence
- (Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Xaa1 Xaa2 Xaa3 Xaa4 Xaa5 Glu Asp Val Gly Ser Asn Lys Gly Ala)n (SEQ ID NO:15)
- wherein n is 1 or 2;
- and
- Xaa1, Xaa2, Xaa3, Xaa4, and Xaa5 are Leu, Val, Phe, Phe, and Ala, respectively, in which one or two of residues Xaa1, Xaa2, Xaa3, Xaa4, and Xaa5 is substituted with Lys, Asp, or Glu.
1 more element
Dependencies are inferred from the claim text.