Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens
AssigneeUnited Biomedical, Inc.
InventorChang Yi Wang
Life of this patent
Estimating the term…
Abstract
The present invention is directed to novel artificial T helper cell epitopes (Th epitopes) designed to provide optimum immunogenicity when used in peptide immunogens comprising B cell epitopes or peptide haptens, a target antigenic site of a target antigen for eliciting antibodies thereto. The artificial Th epitopes are covalently linked to the target antigenic site and and optionally an immunostimulatory sequence to provide effective and safe peptide immunogens.
Claims33
A T helper cell epitope selected from the group consisting of SEQ ID NO:
- 6-22, 105, 123, 124, and 31-35.
A method for producing a peptide immunogen by covalently linking a T helper cell epitope to a target antigenic site selected from the group consisting of B cell epitopes of an antigen and a peptide hapten.
Dependencies are inferred from the claim text.