Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter

A purified nucleic acid molecule comprising the sequence of SEQ ID NO:1.

A purified nucleic acid molecule comprising a sequence selected from the group consisting of SEQ ID NO:2 and SEQ ID NO:5.

An expression vector comprising a nucleic acid sequence encoding a retina-specific ATP binding cassette transporter, wherein said retina-specific ATP binding cassette transporter comprises an amino acid sequence selected from the group consisting of SEQ ID NO:3 and SEQ ID NO:6.

An expression vector comprising a nucleic acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, and SEQ ID NO:5.

A host cell comprising an expression vector, wherein said expression vector comprises the nucleic acid sequence of SEQ ID NO:1.

A host cell comprising an expression vector, wherein said expression vector comprises a nucleic acid sequence selected from the group consisting of SEQ ID NO:2 and SEQ ID NO:5.

A host cell comprising an expression vector, wherein said expression vector comprises a nucleic acid sequence encoding an amino acid sequence selected from the group consisting of SEQ ID NO:3 and SEQ ID NO:6.

A cell culture comprising a culture of cells wherein at least one of said cells comprises an expression vector comprising a nucleic acid molecule encoding a retina-specific ATP binding cassette transporter, wherein said retina-specific ATP binding cassette transporter comprises an amino acid sequence selected from the group consisting of SEQ ID NO:3 and SEQ ID NO:6.

A cell culture comprising a culture of cells wherein at least one of said cells comprises an expression vector comprising a nucleic acid molecule comprising SEQ ID NO:1.

A cell culture comprising a culture of cells wherein at least one of said cells comprises an expression vector comprising a nucleic acid molecule selected from the group consisting of SEQ ID NO:2 and SEQ ID NO:5.

A nucleic acid molecule comprising a nucleic acid sequence identical to SEQ ID NO:2 except wherein said nucleic acid sequence comprises at least one mutation selected from the group consisting of 0223T→ G, 0634C→ T, 0746A→ G, 1018T→ G, 1411G→ A, 1569T→ G, 1715G→ A, 1715G→ C, 1804C→ T, 1822T→ A, 1917C→ A, 2453G→ A, 2461T→ A, 2536G→ C, 2588G→ C, 2791G→ A, 2827C→ T, 2894A→ G, 3083C→ T, 3212C→ T, 3215T→ C, 3259G→ A, 3322C→ T, 3364G→ A, 3385G→ T, 3386G→ T, 3602T→ G, 3610G→ A, 4139C→ T, 4195G→ A, 4222T→ C, 4297G→ A, 4316G→ A, 4319T→ C, 4346G→ A, 4462T→ C, 4469G→ A, 4577C→ T, 4594G→ A, 5041del15, 5281del9, 5459G→ C, 5512C→ T, 5527C→ T, 5657G→ A, 5693G→ A, 5882G→ A, 5908C→ T, 5929G→ A, 6079C→ T, 6088C→ T, 6089G→ A, 6112C→ T, 6148G→ C, 6166A→ T, 6229C→ T, 6286G→ A, 6316C→ T, 6391G→ A, 6415C→ T, 6445C→ T, 6543del36, 0664del13, 2884delC, 4232insTATG, 4947delC, 6709delG, 4253+5G→ T, 5196+2T→ C, 5585+1G→ A, 5714+5G→ A, 5898+1G→ A, and 6005+1G→ T.

A purified nucleic acid molecule comprising a sequence encoding a retina-specific ATP binding cassette transporter comprising a sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:5.

A purified nucleic acid molecule comprising a sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:4, and SEQ ID NO:5.