VZV gene, mutant VZV and immunogenic compositions
AssigneeMedImmune Vaccines, Inc.
InventorGeorge William Kemble
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Abstract
The invention provides for a novel VZV gene, mutant VZV and immunogenic compositions based on such novel genes and mutant VZV. Also provided are proteins, diagnostic assays and methods of producing reconstructed VZV.
Claims8
An isolated or recombinant protein comprising an amino acid sequence selected from the group consisting of the sequences enumerated in SEQ ID NO:12 and 14.
A mutant ORFS/L protein that confers attenuated neurovirulence on a VZV strain making said mutant ORFS/L protein, which mutant ORFS/L protein comprises a mutation that is not present in an ORFS/L protein of a naturally occurring VZV strain, wherein said mutation comprises a deletion of amino acids 99 through 223 of SEQ ID NO:12, and wherein neurovirulence is attenuated as compared to a naturally occurring VZV strain.
A mutant ORFS/L protein that confers attenuated neurovirulence on a VZV strain making said mutant ORFS/L protein, which mutant ORFS/L protein comprises a mutation that is not present in an ORFS/L protein of a naturally occurring VZV strain, wherein said mutation comprises a deletion of amino acids 121 through 157 of SEQ ID NO:14 and replacement of said amino acids with 20 amino acids from a heterologous viral protein not encoded by a genome of a naturally occurring VZV strain, and wherein neurovirulence is attenuated as compared to a naturally occurring VZV strain.
A mutant ORFS/L protein that confers attenuated neurovirulence on a VZV strain making said mutant ORFS/L protein, which mutant ORFS/L protein comprises a mutation that is not present in an ORFS/L protein of a naturally occurring VZV strain, wherein said mutation comprises
- a deletion of at least 10 amino acids,
- wherein neurovirulence is attenuated as compared to a naturally occurring VZV strain.
Dependencies are inferred from the claim text.