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US 6,713,293 B1Granted
Encapsulated cells containing an amplified expression vector as a drug delivery device
OwnerFriedrich Grummt, Birgitta Sauer +1inventors
InventorsFriedrich Grummt, Birgitta Sauer, Martha Müller
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Abstract
The present invention provides a drug delivery device comprising encapsulated cells that contain multiple copies of an expression cassette. The drug delivery device of the present invention is useful to supply an animal, including a human, with a therapeutically desirable molecule, including physiological activities lacking in disease conditions or antagonist against conditions in an animal, especially a human.
Claims21
An encapsulated population of cells comprising
- (a) a eukaryotic cell;
- (b) an exogenous polynucleotide comprising an expression cassette and an amplification-promoting sequence, said eukaryotic cell comprising said polynucleotide, wherein said expression cassette is stably expressed and comprises a nucleic acid encoding an insulin, an insulin precursor polypeptide, a serotonin, a neurotropic factor, a neurotrophic factor, a tyrosine hydroxylase, a tryptophan hydroxylase, an enkephalin, an enkephalin precursor polypeptide, an enkephalinase, a melanoma inhibitory activity and parathyroid hormone and wherein said amplification-promoting sequence comprises a polynucleotide that is capable of hybridizing under highly stringent conditions to a polynucleotide that is complementary to SEQ ID NO:1 or SEQ ID NO:2;
- and
- (c) a capsule, said eukaryotic cell being located in the interior of said capsule.
1 more element
Dependencies are inferred from the claim text.