Methods and composition for the diagnosis and treatment of body weight disorders, including obesity
AssigneeMillennium Pharmaceuticals, Inc.
InventorsKaren Moore, Deborah Lynn Nagle
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AssigneeMillennium Pharmaceuticals, Inc.
InventorsKaren Moore, Deborah Lynn Nagle
Estimating the term…
The present invention relates to mammalian mahogany genes, including the human mahogany gene, which are novel genes involved in the control of mammalian body weight. The invention encompasses nucleotide sequences of the mahogany gene, host cell expression systems of the mahogany gene, and hosts which have been transformed by these expression systems, including transgenic animals. The invention also encompasses novel mahogany gene products, including mahogany proteins, polypeptides and peptides containing amino acid sequences mahogany proteins, fusion proteins of mahogany proteins polypeptides and peptides, and antibodies directed against such mahogany gene products. The present invention also relates to methods and compositions for the diagnosis and treatment of mammalian body weight disorders, including obesity, cachexia, and anorexia, and for the identification of subjects susceptible to such disorders. Further, the invention relates to methods of using the mahogany gene and gene products of the invention for the identification of compounds which modulate the expression of the mahogany gene and/or the activity of the mahogany gene product. Such compounds can be useful as therapeutic agents in the treatment of mammalian body weight disorders, including obesity, cachexia, and anorexia.
An isolated nucleic acid molecule comprising at least 30 contiguous nucleotides of the nucleotide sequence of SEQ ID NO:
An isolated nucleic acid molecule comprising at least 500 contiguous nucleotides of the nucleotide sequence of SEQ ID NO:
An isolated nucleic acid molecule comprising at least 150 contiguous nucleotides of the nucleotide sequence of SEQ ID NO:
An isolated nucleic acid molecule comprising at least 600 contiguous nucleotides of SEQ ID NOs:
An isolated nucleic acid molecule comprising at least 30 contiguous nucleotides of the nucleotide sequence of SEQ ID NO:
An isolated nucleic acid molecule comprising at least 30 contiguous nucleotides of the nucleotide sequence of SEQ ID NO:
An isolated nucleic acid molecule comprising at least 30 contiguous nucleotides of the nucleotide sequence of SEQ ID NO:
Dependencies are inferred from the claim text.