Method for assessing genotoxicity of a compound
AssigneesInstitut National de la Sante et de la Recherche Medicale, Institut Pasteur de Lille
InventorsMarc Pallardy, Daniel Marzin, Sophie Meintieres, Armelle Biola
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Abstract
The invention concerns a method for assessing in vitro the genotoxicity of a compound, which consist in contacting said compound with at least a cell or cell type overexpressing bcl2 protooncogene and/or related anti-apoptotic protein, and observing the genotoxic effects of said compound on said cell.
Claims8
A method for assessing genotoxicity of a compound, in vitro, in which said compound is brought into contact with at least one cell overexpressing a bcl2 proto-oncogene and/or a bcl2-related anti-apoptotic protein, and positive genotoxic effects of said compound on said cell are observed as a) formation of a micronucleus or micronuclei or b) presence of abnormalities of number and/or structure of chromosome in metaphase.
Dependencies are inferred from the claim text.