Detecting genetic predisposition to sight-threatening diabetic retinopathy
AssigneeInterleukin Genetics, Inc.
InventorsGordon W. Duff, Patrick R. S. Richardson, Ian G. Rennie
Life of this patent
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Abstract
A method and kit for predicting increased risk of sight-threatening diabetic retinopathy which includes isolating genomic DNA from a sample from a diabetic patient. The genetic polymorphism pattern for the genes IL-1A, IL-1B and IL-1RN is then identified in the DNA. The identified pattern is compared with control patterns of known polymorphisms, and patients expressing a genetic polymorphism pattern associated with increased risk of sight-threatening diabetic retinopathy are identified.
Claims5
A method of predicting increased risk of sight-threatening diabetic retinopathy, comprising identifying in isolated genomic DNA from a sample previously taken from a diabetic patient a genetic polymorphism pattern comprising a polymorphism selected from the group consisting of:
- IL-1RN (VNTR) allele 1, IL-1 A (−511) allele 2, and IL-1B (−889) allele 2, wherein the presence of the genetic polymorphism pattern is predictive of an increased risk of sight-threatening diabetic retinopathy.
Dependencies are inferred from the claim text.