Method for inhibiting pathogenesis associated with particle-inhalation
AssigneeSanté International, Inc.
InventorArthur DJang
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Abstract
Provided is a method for therapy of a pulmonary disease, the method comprising administering to an individual a composition in an amount effective to inhibit pulmonary inflammation, wherein the composition comprises an extract of Gynostemma pentaphyllum, an extract of Crataegus pinnatifida, and an extract of Camellia sinensis.
Claims20
A method of inhibiting pulmonary disease in an individual comprising administering to an individual an amount of a composition effective to inhibit pulmonary inflammation induced by particle inhalation, wherein the composition comprises about 10 to about 30 percent by weight of a mixture of an aqueous extract and an alcohol extract of Gynostemma pentaphyllum, about 10 to about 30 percent by weight of a mixture of an aqueous extract and an alcohol extract of Camellia sinensis, and about 40 to about 75 percent by weight of a mixture of an aqueous extract and an alcohol extract of Crataegus pinnatifida.
A method of treating of an individual at risk of developing pulmonary disease an amount of a composition effective to inhibit pulmonary inflammation, wherein the composition comprises about 10 to about 30 percent by weight of a mixture of an aqueous extract and an alcohol extract of Gynostemma pentaphyllum, about 10 to about 30 percent by weight of a mixture of an aqueous extract and an alcohol extract of Camellia sinensis, and about 40 to about 75 percent by weight of a mixture of an aqueous extract and an alcohol extract of Crataegus pinnatifida.
A method of treating an individual who has inhaled inorganic dust, the method comprising administering to an individual an amount of a composition effective to inhibit pulmonary inflammation, wherein the composition comprises about 10 to about 30 percent by weight of a mixture of an aqueous extract and an alcohol extract of Gynostemma pentaphyllum, about 10 to about 30 percent by weight of a mixture of an aqueous extract and an alcohol extract of Camellia sinensis, and about 40 to about 75 percent by weight of a mixture of an aqueous extract and an alcohol extract of Crataegus pinnatifida.
A method of inhibiting inflammation, the method comprising contacting alveolar macrophages with an amount of a composition effective to inhibit inflammation measurable by inhibition of one or more of (a) DNA damage to the alveolar macrophages induced by contact of the alveolar macrophages with particles, (b) a decrease in antioxidation enzymes induced by contact of alveolar macrophages with particles, and (c) an increase in reactive oxygen intermediates induced by contact of alveolar macrophages with particles;
- wherein the composition comprises about 10 to about 30 percent by weight of a mixture of an aqueous extract and an alcohol extract of Gynostemma pentaphyllum, about 10 to about 30 percent by weight of a mixture of an aqueous extract and an alcohol extract of Camellia sinensis, and about 40 to about 75 percent by weight of a mixture of an aqueous extract and an alcohol extract of Crataegus pinnatifida.
Dependencies are inferred from the claim text.