Apparatus and method for preparing microparticles
AssigneeAlkermas Controlled Therapeutics Inc. II
InventorsShawn L. Lyons, Steven G. Wright
Life of this patent
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Abstract
Apparatus and method for preparing microparticles. An emulsion is formed by combining two phases in a static mixing assembly. The static mixing assembly preferably includes a preblending static mixer and a manifold. The emulsion flows out of the static mixing assembly into a quench liquid whereby droplets of the emulsion form microparticles. The residence time of the emulsion in the static mixing assembly is controlled to obtain a predetermined particle size distribution of the resulting microparticles.
Claims20
A method of preparing microparticles, comprising:
- combining a first phase and a second phase to form an emulsion, wherein the first phase comprises a polymer, and a solvent;
- flowing the emulsion through a plurality of static mixers;
- and
- combining an outflow of the plurality of static mixers with an extraction liquid for extracting the solvent from the emulsion to form microparticles.
A method for controlling particle size distribution of microparticles, comprising:
- combining a first phase and a second phase in a static mixing assembly to form an emulsion, wherein the first phase comprises a polymer, and a solvent;
- flowing the emulsion into an extraction liquid for extracting the solvent from the emulsion to form microparticles;
- and
- adjusting a residence time of the emulsion in the static mixing assembly to obtain a predetermined particle size distribution of the resulting microparticles, wherein the residence time is equal to a length of the static mixing assembly divided by an average velocity of the emulsion through the static mixing assembly.
Dependencies are inferred from the claim text.