Retrocyclins: antiviral and antimicrobial peptides
AssigneeThe Regents of the University of California
InventorsRobert I. Lehrer, Alan J. Waring, Alexander M. Cole, Teresa B. Hong
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Abstract
Retrocyclin peptides are small antimicrobial agents with potent activity against bacteria and viruses. The peptides are nonhemolytic, and exhibit minimal in vitro cytotoxicity. A pharmaceutical composition comprising retrocyclin as an active agent is administered therapeutically to a patient suffering from a bacterial and/or viral infection, or to an individual facing exposure to a bacterial and/or viral infection, especially one caused by the HIV-1 retrovirus or other sexually-transmitted pathogens.
Claims6
A circular peptide comprising two linked nonapeptides, wherein one nonapeptide has the sequence set forth in SEQ ID NO:74 and one nonapeptide has a sequence selected from the group consisting of SEQ ID NO:19 to SEQ ID NO:64:
- and SEQ ID NO:74 to SEQ ID NO:119.
Dependencies are inferred from the claim text.