Herpes viruses for immune modulation
AssigneeBiovex Limited
InventorRobert S. Coffin
Life of this patent
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Abstract
An attenuated herpes virus which lacks a functional vhs gene or a functional equivalent thereof, but which has a functional UL43 gene or functional equivalent thereof, stimulates an immune response when dendritic cells are infected with the virus.
Claims23
A method of stimulating an immune response in a human or animal subject, which method comprises administering to a subject in need thereof an effective amount of an attenuated herpes virus which:
- (i) lacks a functional vhs gene, or a functional equivalent thereof;
- (ii) lacks a functional gene encoding ICP47, or a functional equivalent thereof;
- (iii) comprises a functional UL43 gene, or a functional equivalent thereof;
- and
- (iv) has a VMW65 gene, or a functional equivalent thereof, which encodes a protein which lacks transcriptional-activation activity.
The method of claim said virus is a herpes simplex virus 1 or 2.
A method of stimulating an immune response in a human or animal subject, which method comprises administering to a subject in need thereof an effective amount of an attenuated herpes virus which:
- (i) lacks a functional vhs gene, or a functional equivalent thereof;
- (ii) lacks a functional gene encoding ICP47, or a functional equivalent thereof;
- (iii) comprises a functional UL43 gene, or a functional equivalent thereof;
- and
- (iv) lacks functional genes encoding ICP0, ICP4, ICP22 and ICP27.
A method of stimulating an immune response in a human or animal subject, which method comprises administering to a subject in need thereof an effective amount of an attenuated heroes virus which:
- (i) lacks a functional vhs gene, or a functional equivalent thereof;
- (ii) lacks a functional gene encoding ICP47, or a functional equivalent thereof;
- (iii) comprises a functional UL43 gene, or a functional equivalent thereof;
- and
- (iv) lacks a functional ICP34.5 gene, or a functional equivalent thereof.
A method of stimulating an immune response in a human or animal subject, which method comprises:
- (a) infecting ex vivo dendritic cells with an attenuated herpes virus, which virus
- (i) lacks a functional vhs gene, or a functional equivalent thereof and
- (ii) comprises a functional UL43 gene or a functional equivalent thereof;
- and
- (b) administering to a subject in need thereof an effective amount of the infected dendritic cells.
The method of wherein said virus is a herpes simplex virus 1 or 2.
Dependencies are inferred from the claim text.