Acinetobacter outer membrane protein and gene sequence compositions and methods
AssigneeThe Regents of the University of Michigan
InventorJuanita L. Merchant
Life of this patent
Estimating the term…
Abstract
Disclosed are new outer membrane proteins and nucleic acids from Acinetobacter and related biological compositions and methods. The biological materials provided are useful in diagnostic, immunological and therapeutic applications, particularly those connected with peptic ulcers and cancers, respiratory diseases, sepsis and a variety of other conditions.
Claims41
A composition comprising at least a first isolated polypeptide that comprises an amino acid sequence that is at least about 90% identical to amino acids 22-349 of the amino acid sequence of SEQ ID NO:2, wherein said isolated polypeptide stimulates IL-8 expression.
A composition comprising at least a first antigenic peptide that consists of the amino acid sequence GSRTVLAEQPVAQ (amino acids 337-349 of SEQ ID NO:2), DTQHNNNGND (amino acids 36-45 of SEQ ID NO:2), TGNYDSKVKP (amino acids 111-120 of SEQ ID NO:2) or YKYEFEGVPRGTRGNEEEG (amino acids 129-147 of SEQ ID NO:2).
A diagnostic kit, comprising a detection reagent in operative association with an isolated polypeptide comprising an amino acid sequence of at least about 90% identity to amino acids 22-349 of SEQ ID NO:2, wherein said isolated polypeptide stimulates IL-8 expression.
A composition comprising a pharmaceutically acceptable carrier or diluent and a therapeutically effective amount of at least a first isolated polypeptide that comprises an amino acid sequence that is at least about 90% identical to amino acids 22-349 of the amino acid sequence of SEQ ID NO:2, wherein said isolated polypeptide stimulates IL-8 expression.
An isolated polypeptide that consists of amino acids 22-349 of the amino acid sequence of SEQ ID NO:2.
A composition comprising a pharmaceutically acceptable carrier or diluent and at least a first isolated peptide that consists of the amino acid sequence GSRTVLAEQPVAQ (amino acids 337-349 of SEQ ID NO:2), DTQHNNNGND (amino acids 36-45 of SEQ ID NO:2) TGNYDSKVKP (amino acids 111-120 of SEQ ID NO:2) or YKYEFEGVPRGTRGNEEEG (amino acids 129-147 of SEQ ID NO:2).
A composition comprising a pharmaceutically acceptable carrier or diluent and a therapeutically effective amount of at least a first isolated polypeptide that consists of amino acids 22-349 of the amino acid sequence of SEQ ID NO:2.
A composition comprising an isolated polypeptide that comprises an amino acid sequence that is at least 90% identical to amino acids 22-349 of the amino acid sequence of SEQ ID NO:2, wherein said isolated polypeptide stimulates IL-8 expression and cross-reacts with an antibody that binds to the Acinetobacter outer membrane protein A (OMP A) protein of SEQ ID NO:2.
A diagnostic kit, comprising a detection reagent in operative association with an isolated polypeptide comprising an amino acid sequence of at least 90% identity to amino acids 22-349 of SEQ ID NO:2, wherein said isolated polypeptide stimulates IL-8 expression and cross-reacts with an antibody that binds to the Acinetobacter outer membrane protein A (OMP A) protein of SEQ ID NO:2.
A composition comprising a pharmaceutically acceptable carrier or diluent and an isolated polypeptide that comprises an amino acid sequence that is at least 90% identical to amino acids 22-349 of the amino acid sequence of SEQ ID NO:2, wherein said isolated polypeptide stimulates IL-8 expression and cross-reacts with an antibody that binds to the Acinetobacter outer membrane protein A (OMP A) protein of SEQ ID NO:2.
A composition comprising an isolated peptide fragment of from 8 to about 50 amino acids in length that consists of an amino acid sequence that is identical to a contiguous g amino acid sequence of at least from 8 amino acids from amino acids 22-349 of amino acid sequence of SEQ ID NO:2.
A composition comprising an isolated antigenic peptide of from 8 to about 50 amino acids in length that consists of an amino acid sequence that is identical to a contiguous amino acid sequence of at least from 8 amino acids from amino acids 22-349 of the amino acid sequence of SEQ ID NO:2, wherein said isolated antigenic peptide cross-reacts with an antibody binds to the Acinetobacter outer membrane protein A (OMP A) protein of SEQ ID NO:2.
Dependencies are inferred from the claim text.