Death domain containing receptors
AssigneeHuman Genome Sciences, Inc.
InventorsGuo-Liang Yu, Jian Ni, Vishva M. Dixit, Reiner L. Gentz, Patrick J. Dillon
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Abstract
The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
Claims12
An isolated polypeptide comprising an amino acid sequence at least 90% identical to amino acids 30 to 215 of SEQ ID NO:2, wherein said polypeptide inhibits apoptosis.
An isolated polypeptide comprising an amino acid sequence at least 90% identical to the mature amino acid sequence encoded by the cDNA clone contained in ATCC Deposit No. 97456, wherein said polypeptide induces apoptosis.
Dependencies are inferred from the claim text.