Compositions and methods for modulating serum cholesterol
AssigneeThe Johns Hopkins University
InventorSubroto Chatterjee
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Abstract
Compositions and methods are provided for modulating serum cholesterol in a subject mammal. In one aspect, the invention features novel anti-lipemic drugs that include at least one identified effector of the Low Density Lipoprotein (LDL) receptor and at least one identified serum cholesterol inhibitor. In a particular aspect, the drugs include one identified sphingolipid or protein modifying same linked to one identified serum cholesterol inhibitor. Additionally provided are methods for identifying anti-lipemic drugs capable of modulating the LDL receptor and specifically SREBP-1 maturation, including assays designed to identify pharmacological drugs capable of stabilizing or reducing serum cholesterol levels in a mammal and particularly a human patient.
Claims12
A method for modulating serum cholesterol level in a mammal, wherein the method comprises administering to the mammal a therapeutically effective amount of an anti-lipemic drug comprising at least one effector of the sterol regulatory element binding protein 1 (SREBP-1) and at least one identified serum cholesterol inhibitor, wherein the SREBP-1 effector is a sphingolipid.
Dependencies are inferred from the claim text.